Impacts of Maternal Noise Exposure on Risk of Stillbirth and Oxidative Stress-Induced Neurobehavioral Changes in Offspring

Life does not start at birth but conception. Embryonic development is a particularly difficult period in which genetic and environmental factors can interact to contribute risk. In utero early neonatal exposure maternal stress are linked with psychiatric disorders, the underlying mechanisms currently being elucidated. This study examined novel relationships between noise causing oxidative-stress-induced neurobehavioral changes cognition autism spectrum disorder (ASD) offspring. Pregnant Wistar albino rats were exposed (100 dBA/4 h). There three groups of pregnant during gestation, as well control group: gestational (EGS), occurs 1st 10th days pregnancy; late (LGS), 11th day delivery day; full-term (FGS), entire pregnancy period. Maternal effects on offspring analyzed. observed that becomes psychosocial stressor prenatal motherhood. EGS LGS groups, female showed continuous midterm abortion stillbirth exposure. The noise-exposed group exhibited significant cognition, obsessive–compulsive behavior, fear, anxiety. Corticosterone oxidative markers increased, antioxidant level was significantly decreased group. Therefore, causes recurrent abortions stillbirths, increases stress, impairs offspring’s neurodevelopment.